溶解度
药物发现
药物开发
药品
管道(软件)
化学
纳米技术
计算机科学
组合化学
生化工程
材料科学
有机化学
药理学
工程类
医学
生物化学
程序设计语言
作者
Jaclyn A. Barrett,Wenzhan Yang,Suzanne Skolnik,Lisa M Belliveau,Kellyn M Patros
标识
DOI:10.1016/j.drudis.2022.01.017
摘要
Solubility is a key physicochemical property for the success of any drug candidate. Although the methods used and their rationales for determining solubility are subject to project needs and stages along the drug discovery-drug development pipeline, an artificial boundary can exist at the discovery-development interface. This boundary results in less effective solubility knowledge sharing and data integration among scientists in both drug discovery and drug development. Herein, we present a refreshed perspective on solubility. Solubility experimentation is not a one-size-fits-all measurement; instead, we stress the importance of constructing a seamless solubility understanding of a molecule as it progresses from a new chemical entity into a drug product.
科研通智能强力驱动
Strongly Powered by AbleSci AI