Uterine adenomyosis is defined by the presence of heterotopic endometrial glands and stroma at the myometrial level. Although imagistic studies improved, the incidence of adenomyosis is still underestimated, in a significant number of cases the final diagnostic of adenomyosis being established on the histopathological specimen of hysterectomy. The aim of the current paper is to discuss about the most efficient therapeutic strategies in adenomyosis.