Wnt信号通路
化学
连环素
转录因子
过度活跃
细胞生物学
信号转导
连环蛋白
辅活化剂
抄写(语言学)
胚胎干细胞
癌症研究
生物
生物化学
基因
语言学
哲学
作者
Emma M R Koelman,Alejandro Yeste-Vázquez,Tom N. Grossmann
标识
DOI:10.1016/j.bmc.2022.116920
摘要
The Wnt/β-catenin signaling pathway is crucially involved in embryonic development, stem cell maintenance and tissue renewal. Hyperactivation of this pathway is associated with the development and progression of various types of cancers. The transcriptional coactivator β-catenin represents a pivotal component of the pathway and its interaction with transcription factors of the TCF/LEF family is central to pathway activation. Inhibition of this crucial protein–protein interaction via direct targeting of β-catenin is considered a promising strategy for the inactivation of oncogenic Wnt signaling. This review summarizes advances in the development of Wnt antagonists that have been shown to directly bind β-catenin.
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