急性肾损伤
转录因子
NF-κB
病理生理学
肾
炎症
抄写(语言学)
细胞生物学
缺氧诱导因子
癌症研究
生物
化学
NFKB1型
缺氧(环境)
医学
基因
免疫学
病理
内科学
遗传学
氧气
语言学
有机化学
哲学
作者
Zuo‐Lin Li,Jialing Ji,Yi Wen,Jun Cao,Naresh Kharbuja,Wei-Jie Ni,Di Yin,Songtao Feng,Hong Liu,Lin‐Li Lv,Bi‐Cheng Liu,Bin Wang
出处
期刊:American Journal of Physiology-renal Physiology
[American Physiological Society]
日期:2021-08-01
卷期号:321 (2): F225-F235
被引量:14
标识
DOI:10.1152/ajprenal.00119.2021
摘要
Here, the mechanism of hypoxia-inducible factor-α (HIF-α) regulation in acute kidney injury (AKI) was investigated. We found that tubular HIF-1α expression significantly increased at the transcriptional level, which was closely associated with macrophage-dependent inflammation. Meanwhile, NF-κB was involved in the increasing expression of HIF-1α in AKI. Mechanistically, NF-κB directly bound to the HIF-1α promoter and enhanced its transcription. Our findings not only provide novel insights into HIF-1 regulation in AKI but also offer to understand the pathophysiology of kidney diseases.
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