Papillary Thyroid Carcinoma Landscape and Its Immunological Link With Hashimoto Thyroiditis at Single-Cell Resolution

甲状腺癌 生物 癌症研究 甲状腺炎 甲状腺癌 肿瘤微环境 转移 单细胞分析 甲状腺 免疫系统 细胞 病理 癌症 免疫学 医学 内分泌学 遗传学
作者
Jun Pan,Fang Ye,Chengxuan Yu,Qinsheng Zhu,Jiaqi Li,Yaohui Zhang,Hedi Tian,Yunjin Yao,Man Zhu,Yi-Bin Shen,Feng Zhu,Yingying Wang,Xinhui Zhou,Guoji Guo,Yijun Wu
出处
期刊:Frontiers in Cell and Developmental Biology [Frontiers Media]
卷期号:9 被引量:16
标识
DOI:10.3389/fcell.2021.758339
摘要

The tumor microenvironment heterogeneity of papillary thyroid cancer (PTC) is poorly characterized. The relationship between PTC and Hashimoto thyroiditis (HT) is also in doubt. Here, we used single-cell RNA sequencing to map the transcriptome landscape of PTC from eight PTC patients, of which three were concurrent with HT. Predicted copy number variation in epithelial cells and mesenchymal cells revealed the distinct molecular signatures of carcinoma cells. Carcinoma cells demonstrated intertumoral heterogeneity based on BRAF V600E mutation or lymph node metastasis, and some altered genes were identified to be correlated with disease-free survival in The Cancer Genome Atlas datasets. In addition, transcription factor regulons of follicular epithelial cells unveil the different transcription activation state in PTC patients with or without concurrent HT. The immune cells in tumors exhibited distinct transcriptional states, and the presence of tumor-infiltrating B lymphocytes was predominantly linked to concurrent HT origin. Trajectory analysis of B cells and plasma cells suggested their migration potential from HT adjacent tissues to tumor tissues. Furthermore, we revealed diverse ligand–receptor pairs between non-immune cells, infiltrating myeloid cells, and lymphocytes. Our results provided a single-cell landscape of human PTC. These data would deepen the understanding of PTC, as well as the immunological link between PTC and HT.
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