Sepsis-related coagulopathy

Disseminated intravascular coagulation(DIC) remains a challenging syndrome for intensivists, as the markers enabling its identification are lacking, and the treatment is patient dependent.The process underlying DIC is a complex interlinked framework of proteases of both the coagulation and inflammatory cascades, thus explaining the difficulty in DIC management.Identification can be accomplished with scoring systems such as the DIC score, and treatment begins with identification and treatment of the underlying infectious cause.Supportive care and correction of coagulopathies should be provided simultaneously to prevent irreversible end-organ injury and DIC progression. Key words: Sepsis; Disseminated intravascular coagulation; Coagulopathy