紫杉醇
药物输送
细胞毒性
生物相容性
胶质母细胞瘤
喜树碱
化学
体外
癌症研究
材料科学
纳米技术
生物
生物化学
化疗
遗传学
有机化学
作者
Jyothi B. Nair,Saswat Mohapatra,Manu M. Joseph,Santhi Maniganda,Varsha Gupta,Surajit Ghosh,Kaustabh Kumar Maiti
出处
期刊:ACS Biomaterials Science & Engineering
[American Chemical Society]
日期:2020-08-05
卷期号:6 (9): 5254-5263
被引量:5
标识
DOI:10.1021/acsbiomaterials.0c00717
摘要
The design and development of an efficacious tumor-specific drug-delivery system is a challenging task. In this study, we have synthesized target-specific small peptide substrates on an octaguanidine sorbitol scaffold, named small molecular targeted drug-delivery conjugate (SMTDDC). The SMTDDC fabrication, with dual targeting cRGD and Cathepsin B (Cath B)-specific tripeptide (Glu-Lys-Phe), altered the microtubule network of glioblastoma cells by the orchestrated release of the cytotoxic paclitaxel (PTX). Cath B assisted PTX delivery was monitored by high-performance liquid chromatography and Surface-Enhanced Raman Scattering (SERS) modalities. The time-dependent SERS fingerprinting and imaging revealed a fast and accurate PTX release profile and subsequent in vitro cytotoxicity as well as the apoptotic events and microtubule network alteration in U-87 MG glioblastoma cells. Furthermore, SMTDDC displayed adequate stability under physiological conditions and demonstrated biocompatibility toward red blood cells and lymphocytes. This study indicated a new insight on SERS-guided peptidomimetic sorbitol molecular transporter, enabling a greater promise with high potential for the further development of PTX delivery in glioblastoma treatment.
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