生物材料
组织工程
生化工程
细胞培养
三维细胞培养
纳米技术
材料科学
生物医学工程
计算机科学
工程类
生物
遗传学
作者
Kyle G. Battiston,Jane W.C. Cheung,Devika Jain,J. Paul Santerre
出处
期刊:Biomaterials
[Elsevier]
日期:2014-05-01
卷期号:35 (15): 4465-4476
被引量:117
标识
DOI:10.1016/j.biomaterials.2014.02.023
摘要
Most natural tissues consist of multi-cellular systems made up of two or more cell types. However, some of these tissues may not regenerate themselves following tissue injury or disease without some form of intervention, such as from the use of tissue engineered constructs. Recent studies have increasingly used co-cultures in tissue engineering applications as these systems better model the natural tissues, both physically and biologically. This review aims to identify the challenges of using co-culture systems and to highlight different approaches with respect to the use of biomaterials in the use of such systems. The application of co-culture systems to stimulate a desired biological response and examples of studies within particular tissue engineering disciplines are summarized. A description of different analytical co-culture systems is also discussed and the role of biomaterials in the future of co-culture research are elaborated on. Understanding the complex cell–cell and cell–biomaterial interactions involved in co-culture systems will ultimately lead the field towards biomaterial concepts and designs with specific biochemical, electrical, and mechanical characteristics that are tailored towards the needs of distinct co-culture systems.
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