一致性
危险系数
置信区间
医学
样本量测定
统计
平均差
平淡——奥特曼情节
癌症存活率
协议限制
内科学
核医学
数学
癌症
作者
Jordi Martínez,José Antonio García-Cruces González,Michael J. Campbell,Erik Cobo
标识
DOI:10.1016/j.jclinepi.2014.05.017
摘要
Objectives To evaluate the empirical concordance between the hazard ratio (HR) and the median ratio (MR) in survival cancer studies. Study Design and Setting We selected all cancer survival articles from the New England Journal of Medicine published between 2000 and 2010. The qualitative concordance was estimated by the proportion of measured pairs in which the treatment effects for the MR and HR are in the same direction. The quantitative concordance was assessed through (1) the mean difference between the logarithms of the measures, (2) the Lin coefficient, and (3) the Bland–Altman plot. Results We retrieved 106 measured pairs (HR–MR) corresponding to 54 articles. Concordance was high, at both the qualitative (99 of 106, 93.4%) and quantitative levels (mean MR-to-HR ratio, 1.01; 95% confidence interval: 0.95, 1.06). However, the 95% Bland–Altman discordance limits indicate that the MR can be up to 50% higher or 50% lower than the HR. Conclusion The average concordance allows trialists to approximate HR from MR to determine sample size. However, the discordance limits are too great to consider that both measures are interchangeable. The actual policy to report HR only is not enough. Our results emphasize the need to attach descriptive survival measures to the HR.
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