生物
拟南芥
RNA聚合酶Ⅱ
转录因子
基因
调解人
抄写(语言学)
遗传学
组蛋白
细胞生物学
终端(太阳能)
基因表达调控
一般转录因子
突变体
WRKY蛋白质结构域
发起人
基因表达
哲学
物理
电离层
天文
语言学
作者
Zhibing Lai,Craig Schluttenhofer,Ketaki P. Bhide,Jacob Shreve,Jyothi Thimmapuram,Sang Yeol Lee,Dae‐Jin Yun,Tesfaye Mengiste
摘要
Mediator is an evolutionarily conserved transcriptional regulatory complex. Mechanisms of Mediator function are poorly understood. Here we show that Arabidopsis MED18 is a multifunctional protein regulating plant immunity, flowering time and responses to hormones through interactions with distinct transcription factors. MED18 interacts with YIN YANG1 to suppress disease susceptibility genes glutaredoxins GRX480, GRXS13 and thioredoxin TRX-h5. Consequently, yy1 and med18 mutants exhibit deregulated expression of these genes and enhanced susceptibility to fungal infection. In addition, MED18 interacts with ABA INSENSITIVE 4 and SUPPRESSOR OF FRIGIDA4 to regulate abscisic acid responses and flowering time, respectively. MED18 associates with the promoter, coding and terminator regions of target genes suggesting its function in transcription initiation, elongation and termination. Notably, RNA polymerase II occupancy and histone H3 lysine tri-methylation of target genes are affected in the med18 mutant, reinforcing MED18 function in different mechanisms of transcriptional control. Overall, MED18 conveys distinct cues to engender transcription underpinning plant responses.
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