The influence of sodium hexametaphosphate on the dispersion behavior of nano hydroxyapatite in water was studied by the determination of particle distribution and zeta potential of nano hydroxyapatite in sodium hexametaphosphate solution. Results show that, the hydroxyapatite can exist in a wide concentration of sodium hexametaphosphate. The sodium hexametaphosphate is a benign dispersant for hydroxyapatite. A highly dispersed sol was obtained when NaP/HA=12.5 (weight ratio). The sol contains 88% hydroxyapatite particles with size in the range of 65~86nm.