Progress in effects mechanism of tetramethylpyrazine in the treatment of hepatic fibrosis

Chronic liver injury,including viral hepatitis,alcoholism,drugs and metabolic diseases,lead to hepatic fibrosis. Hepatic fibrosis is a reversible process,but liver cirrhosis resulted from progress of hepatic fibrosis is not reversible. Thus,early diagnosis in the fibrosis stage and timely effective treatment can slow or prevent the development of liver cirrhosis. In recent years,tetramethylpyrazine ,an active ingredients in Chuanxiong has played good therapeutic effect in the treatment of hepatic fibrosis. This paper reviewed the effect and mechanism of tetramethylpyrazine in the treatment of hepatic fibrosis.