Objective To discuss the relationship between hypoalbuminemia and 7kind of Elements in Sever Stroke Patients.Methods A case-control study was carried out among 200 sever stroke patients,they were divided into the hypoalbuminemia group(ALB 30-35g/L 76 patients,ALB 25-30g/L 48 patients,ALB25g/L 8patients)and the control group(ALB≥35g/L 68patients).Determination of human serum album and 7kind of elements' content in the 200 patients venous blood was done on the 7th day in the hospital.Comparison was made in the differences of 7kind of elements between the case group and the control group.Results The differences of the 7kind of elements′content in patients between the case group and the control group were not statistically significant(P 0.05),which were not risk factors of the onset of hypoalbuminemia with sever stroke(P 0.05).Conclusion In the short term,the 7kind of elements′content in severe stroke patients has no effect on the onset of hypoalbuminemia.