As for its multi-spectral and high spatial resolution( 0. 46 meters),coupling with its function of abundant information and clear images,the World View-2 state images has been quickly used in various industries since published. The previous results of the land desertification monitoring of Guangxi were not so good because of the low resolution of the Remote Sensing Image. Aiming to improve the efficiency and accuracy of the results for land desertification monitoring,the World View-2 Remote Sensing Images was used in the fifth land desertification monitoring of Guangxi Province. In this paper,the method of how to use the World View-2 Remote Sensing Images in desertification monitoring of Guangxi by clarify the processing of the remote sensing image,the building of the remote sensing image visual interpretation symbol library,the interpretation of the remote sensing image and the nuclear results etc.,have been discussed.The results indicated that the application of World View-2 Remote Sensing Images in the fifth land desertification monitoring of Guangxi was feasible..