Regenerative tissue remodeling in planarians – The mysteries of morphallaxis

Biologists have long marveled at the ability of planarian flatworms to regenerate any parts of their bodies in just a little over a week. While great progress has been made in deciphering the mechanisms by which new tissue is formed at sites of amputation, we know relatively little about the complementary remodeling response that occurs in uninjured tissues to restore anatomical scale and proportion. This review explores the mysterious biology of this process, first described in hydra by the father of experimental zoology, Abraham Trembley, and later termed 'morphallaxis' by the father of experimental genetics, Thomas Hunt Morgan. The perceptive work of these early pioneers, together with recent studies using modern tools, has revealed some of the key features of regenerative tissue remodeling, including repatterning of the body axes, reproportioning of organs like the brain and gut, and a major increase in the rate of cell death. Yet a mechanistic solution to this longstanding problem in the field will require further study by the next generation of planarian researchers.