癌相关成纤维细胞
癌症研究
表观遗传学
癌症
癌细胞
脂质代谢
生物
肿瘤微环境
氧化磷酸化
胰腺癌
胰腺导管腺癌
细胞生物学
功能(生物学)
肿瘤细胞
内分泌学
生物化学
遗传学
基因
作者
Xiongfeng Chen,Xiongfeng Chen,Huocong Huang,Huocong Huang,Huocong Huang
标识
DOI:10.1016/j.ccell.2024.04.001
摘要
Cancer-associated fibroblasts (CAFs) exhibit spatial and functional diversity. Here, Niu et al. unveil SETD2's function in lipid metabolism and CAF heterogeneity in pancreatic ductal adenocarcinoma. SETD2 deficiency boosts oxidative phosphorylation activity, prompting lipid-laden CAF formation through BMP2 signaling, offering promising therapeutic avenues in personalized cancer treatment.
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