充氧
胎盘
人胎盘
血流动力学
医学
高氧
超声波
血液氧合
胎盘循环
血液取样
生物医学工程
光学成像
怀孕
心脏病学
胎儿
放射科
内科学
生物
肺
遗传学
物理
光学
功能磁共振成像
作者
Lin Wang,Jeffrey M. Cochran,Tiffany Ko,Wesley B. Baker,Kenneth Abramson,Lian He,David R. Busch,Venki Kavuri,Rebecca L. Linn,Samuel Parry,Arjun G. Yodh,Nadav Schwartz
标识
DOI:10.1038/s41551-022-00913-2
摘要
Direct assessment of blood oxygenation in the human placenta can provide information about placental function. However, the monitoring of placental oxygenation involves invasive sampling or imaging techniques that are poorly suited for bedside use. Here we show that placental oxygen haemodynamics can be non-invasively probed in real time and up to 4.2 cm below the body surface via concurrent frequency-domain diffuse optical spectroscopy and ultrasound imaging. We developed a multimodal instrument to facilitate the assessment of the properties of the anterior placenta by leveraging image-reconstruction algorithms that integrate ultrasound information about the morphology of tissue layers with optical information on haemodynamics. In a pilot investigation involving placentas with normal function (15 women) or abnormal function (9 women) from pregnancies in the third trimester, we found no significant differences in baseline haemoglobin properties, but statistically significant differences in the haemodynamic responses to maternal hyperoxia. Our findings suggest that the non-invasive monitoring of placental oxygenation may aid the early detection of placenta-related adverse pregnancy outcomes and maternal vascular malperfusion.
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