Exogenous All-TransRetinoic Acid Induces Myopia and Alters Scleral Biomechanics in Mice

In mice, atRA treatment results in an axial myopia phenotype. Eyes developed myopic RE and larger VCD without the anterior eye being affected. The decrease in stiffness and increase in permeability of the sclera are consistent with the form-deprivation myopia phenotype.