Biodegradable photothermal thermosensitive hydrogels treat osteosarcoma by reprogramming macrophages

, the local administration of HTA + NIR exerted photothermal killing of primary tumors and reprogramming of TAMs into M1-type macrophages in the TME. Therefore, the injectable photothermally active antitumor hydrogel has great potential for modulating the TME to treat bone tumors.