CXCR3型
CCL5
生物
免疫学
CXCL10型
CX3CL1型
CCL19型
CXCL16型
趋化因子
白细胞介素21
归巢(生物学)
CD40
C-C趋化因子受体7型
趋化因子受体
细胞毒性T细胞
T细胞
白细胞介素2受体
炎症
免疫系统
体外
生物化学
生态学
作者
Debora Giunti,Giovanna Borsellino,Roberto Benelli,Monica Marchese,Elisabetta Capello,Maurizio Valle,Enrico Pedemonte,Douglas M. Noonan,Adriana Albini,Giorgio Bernardi,Gianluigi Mancardi,Luca Battistini,Antonio Uccelli
摘要
The recruitment of lymphocytes across the blood brain barrier (BBB) is mediated by adhesion molecules and chemokines. The expression of activation markers and of chemokine receptors on T cells homing to the nervous system (NS) may help define their functional state. In the cerebrospinal fluid (CSF) of subjects with inflammatory neurological diseases (IND), including multiple sclerosis, we observed an increased number of T cells coexpressing CXCR3 and CCR5 as well as T cells with a CD45RO+ CCR7+ CD27+ memory phenotype. A subset of CCR7+ T cells coexpressed CXCR3 and CCR5. We also detected an increased number of interferon-gamma-producing T cells in the CSF compared with peripheral blood, mostly but not exclusively in the CD45RO+ CCR7- CD27- compartment. T helper 1 (Th1) clones, established from the CSF of individuals with IND and from a healthy subject, similarly migrated to CXCL10, CXCL12, and CCL5. CXCL10, CXCL12, and CCL19 were increased in the CSF of individuals with neuroinflammation. These findings suggest that CSF is enriched in Th1-polarized memory T cells capable of differentiating into effector cells upon antigen encounter. These cells are recruited into the CSF by inducible chemokines. Thus, CSF represents a transitional station for T cells trafficking to and from the NS.
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