Inside Back Cover: Programmable Antigen‐Specific Immunity via Self‐Adjuvanting Nanovaccines Co‐Delivering Immune Modulators (Angew. Chem. Int. Ed. 11/2026)

Self-adjuvanting vaccines—covalent conjugates of antigens and adjuvants—elicit robust antigen-specific immunity. In the Research Article (e20474), Yoshiyuki Manabe, Yoshie Kametani, Koichi Fukase, and co-workers formulated self-adjuvanting vaccines into cationic lipid nanoparticles (< 100 nm) incorporating supplemental adjuvants. These nanovaccines exhibited potent immunogenicity in humanized mouse models, underscoring their translational potential for cancer immunotherapy.