精神运动学习
认知
精神病
医学
内科学
睡眠剥夺对认知功能的影响
精神科
作者
Núria Pujol,Daniel Bergé,Anna Mané,Miquel Bioque,Gisela Mezquida,Sílvia Amoretti,Inmaculada Baeza,Ana González-Pinto,Antonio Lobo,Manuel J. Cuesta,Maria Helena Ribeiro,Georgina Sánchez-Tomico,Víctor Pérez‐Solà,Norma Verdolini,Eduard Vieta,Mara Parellada,Alexandra Roldán,Miquel Bernardo
标识
DOI:10.1016/j.psychres.2022.114760
摘要
To explore the influence of cardiovascular risk factors (CVRFs) on cognitive symptoms, functional impairment, and systemic inflammatory markers in first-episode psychosis (FEP) patients at baseline and 2-year follow-up. Method: In a sample of 70 FEP patients and 85 age- and sex-matched healthy controls, we assessed nine modifiable CVRFs. All participants were classified into two subgroups according to their CVRF profile: lower (0–1 CVRFs) or higher (≥2 CVRFs). The following outcomes were measured at baseline and 2-year follow-up: cognition; functional outcomes; and white blood cell (WBC) subtype. Adjusted general linear models were conducted to study the effect of diagnosis and CVRF profile on cognition, functioning, WBC, and longitudinal changes in these variables. At baseline, FEP patients with a higher CVRF profile showed a significantly slower performance on the TMT-A test for psychomotor speed and higher lymphocyte levels than patients with a lower CVRF profile. No longitudinal changes were observed in primary outcomes at 2-year follow-up. Among FEP patients with a higher CVRF profile, slower psychomotor speed performance did not correlate with increased lymphocyte levels. Our findings suggest that the cognitive effects of CVRFs manifest early in the course of psychosis, thus highlighting the importance of targeting both CVRFs and cognitive deficits in FEP.
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