Rapid and sustained improvement of cutaneous lichen planus with oral JAK1 inhibitors

Journal of the European Academy of Dermatology and VenereologyEarly View LETTER TO THE EDITOR Rapid and sustained improvement of cutaneous lichen planus with oral JAK1 inhibitors Simone L. Böll, Corresponding Author Simone L. Böll [email protected] orcid.org/0000-0001-7762-985X Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland Correspondence Simone L. Böll, Inselspital, Bern University Hospital, Freiburgstr. 34, Bern 3010, Switzerland. Email: [email protected]Search for more papers by this authorCarole A. Zahn, Carole A. Zahn Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, SwitzerlandSearch for more papers by this authorChristoph Schlapbach, Christoph Schlapbach orcid.org/0000-0003-0258-1243 Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, SwitzerlandSearch for more papers by this author Simone L. Böll, Corresponding Author Simone L. Böll [email protected] orcid.org/0000-0001-7762-985X Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland Correspondence Simone L. Böll, Inselspital, Bern University Hospital, Freiburgstr. 34, Bern 3010, Switzerland. Email: [email protected]Search for more papers by this authorCarole A. Zahn, Carole A. Zahn Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, SwitzerlandSearch for more papers by this authorChristoph Schlapbach, Christoph Schlapbach orcid.org/0000-0003-0258-1243 Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, SwitzerlandSearch for more papers by this author First published: 18 August 2023 https://doi.org/10.1111/jdv.19440Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat REFERENCES 1Lehman JS, Tollefson MM, Gibson LE. Lichen planus. Int J Dermatol. 2009; 48(7): 682–694. 2Boch K, Langan EA, Kridin K, Zillikens D, Ludwig RJ, Bieber K. Lichen planus. Front Med (Lausanne). 2021; 8:737813. 3Pietschke K, Holstein J, Meier K, Schäfer I, Müller-Hermelink E, Gonzalez-Menendez I, et al. The inflammation in cutaneous lichen planus is dominated by IFN-ϒ and IL-21-a basis for therapeutic JAK1 inhibition. Exp Dermatol. 2021; 30(2): 262–270. 4Shao S, Tsoi LC, Sarkar MK, Xing X, Xue K, Uppala R, et al. IFN-γ enhances cell-mediated cytotoxicity against keratinocytes via JAK2/STAT1 in lichen planus. Sci Transl Med. 2019; 11(511): 2–9. 5Abduelmula A, Bagit A, Mufti A, Yeung KCY, Yeung J. The use of Janus kinase inhibitors for lichen planus: an evidence-based review. J Cutan Med Surg. 2023; 27: 271–276. 6Didona D, Caposiena Caro RD, Sequeira Santos AM, Solimani F, Hertl M. Therapeutic strategies for oral lichen planus: state of the art and new insights. Front Med (Lausanne). 2022; 9:997190. 7Klein B, Treudler R, Simon JC. JAK-inhibitors in dermatology – small molecules, big impact? Overview of the mechanism of action, previous study results and potential adverse effects. J Dtsch Dermatol Ges. 2022; 20(1): 19–24. 8Fiocco Z, Kupf S, Patzak L, Kämmerer T, Pumnea T, French LE, et al. Quality of life and psychopathology in lichen planus: a neglected disease burden. Acta Derm Venereol. 2021; 101(12):adv00619. 9Samuel C, Cornman H, Kambala A, Kwatra SG. A review on the safety of using JAK inhibitors in dermatology: clinical and laboratory monitoring. Dermatol Therapy. 2023; 13(3): 729–749. Early ViewOnline Version of Record before inclusion in an issue ReferencesRelatedInformation