Aquaporin 4 and its isoforms regulation ameliorate AQP4 Mis-localization-induced glymphatic dysfunction in ischemic stroke

Cerebral edema disrupts AQP4 localization and glymphatic function following stroke. TGN-020 modulates AQP4 polarization through regulation of AQP4 isoforms and restores glymphatic dysfunction. AQP4-M23 isoform emerges as a key regulator of AQP4 polarization, providing new insights into ischemic stroke pathophysiology.