生物
基因组
遗传学
DNA
基因
同源重组
直接重复
DNA修复
同源染色体
DNA损伤
基因组不稳定性
基因重排
计算生物学
细胞生物学
作者
Ragini Bhargava,David O. Onyango,Jeremy M. Stark
标识
DOI:10.1016/j.tig.2016.06.007
摘要
Single-strand annealing (SSA) is a DNA double-strand break (DSB) repair pathway that uses homologous repeats to bridge DSB ends. SSA involving repeats that flank a single DSB causes a deletion rearrangement between the repeats, and hence is relatively mutagenic. Nevertheless, this pathway is conserved, in that SSA events have been found in several organisms. In this review, we describe the mechanism of SSA and its regulation, including the cellular conditions that may favor SSA versus other DSB repair events. We will also evaluate the potential contribution of SSA to cancer-associated genome rearrangements, and to DSB-induced gene targeting.
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