发病机制
白塞病
CD64
免疫学
单核细胞
表型
人口
整合素αM
疾病
医学
生物
内科学
免疫系统
遗传学
抗原
基因
环境卫生
作者
Chaoran Li,Jinjing Liu,Xin Yu,Lü Li,Zhimian Wang,Jing Shi,Xiaofeng Zeng,Fengchun Zhang,Hua Chen,Wenjie Zheng
标识
DOI:10.1016/j.clim.2021.108683
摘要
Monocytes are a versatile and dynamic population, but its implication in Behçet's Disease (BD) remains elusive. We investigated the proportion, phenotypical and functional alterations in classical monocytes (CM), intermediate monocytes (IM) and non-classical monocytes (NCM) subsets in BD. A higher IM and lower NCM population in BD patients were noted, closely correlated with disease activity, and rescued after treatment. CD11b and CD64 expression on CM, IM and NCM in BD were enhanced. BD CM promoted TNF-a and IL-6 production and facilitated Th1 differentiation. BD IM promoted IL-6 production. We further demonstrated a higher level of phosphorylated p65 (p-p65) in BD CM and increased p-p65 and p-p38 in BD IM. Our data highlighted the aberrant populations of IM and CM in BD, potentially implicated in BD' pathogenesis.
科研通智能强力驱动
Strongly Powered by AbleSci AI