Pharmaceutical‐Oriented Iron‐Catalyzed Ethoxylation of Aryl C( sp 2 )‐H Bonds with Cobalt Co–Catalyst

Abstract A novel and mild pharmaceutical‐oriented iron‐catalyzed ethoxylation of aryl C( sp 2 )‐H bonds with cobalt co‐catalyst was successfully developed. The reaction occurs efficiently with broad substrate scope tolerance and high regioselectivity. It's the first example of C−H alkoxylation using inexpensive and low biotoxicity iron as a catalyst.