Ambient Pressure Asymmetric Imine Hydrogenation

Significance Using an Ir(I)-ddppm complex, a variety of aromatic imines could be hydrogenated to chiral secondary amines with excellent yields and very good enantioselectivities. The key aspect of these reactions is that they were performed at ambient temperatures and 1 atm of H 2(g) . Interestingly, increasing the pressure of H 2(g) led to erosion of enantioselectivity.