生物转化
黑曲霉
化学
水解
吡啶
立体化学
生物化学
有机化学
酶
出处
期刊:PubMed
日期:2015-11-01
卷期号:28 (6): 1933-7
被引量:1
摘要
The biotransforamtion of swertiamarin has been carried out using Aspergillus niger. The results showed that 60% swertiamarin were metabolized into two metabolites during the 5 days of biotransformation. The metabolites were identified as erythrocentaurin and 5-ethylidene-8-hydroxy-3,4,5,6,7,8-hexahydro-1Hpyrano[3,4-c]-pyridine-1-one, a novel alkaloid, with NMR and MS. The hydrolysis of glucosidic bond catalyzed by β-D-glucosidase was found to be the rate-limiting reaction in pathway of biotransformation of swertiamarin.
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