医学
高钙血症
原发性甲状旁腺功能亢进
穿孔
背景(考古学)
甲状旁腺功能亢进
胃肠病学
病理生理学
内科学
疾病
消化性溃疡
甲状旁腺激素
消化性
钙
古生物学
材料科学
生物
冲孔
冶金
作者
Cameron Castle,James Tietjens
出处
期刊:Case Reports
[BMJ]
日期:2021-04-01
卷期号:14 (4): e240570-e240570
被引量:2
标识
DOI:10.1136/bcr-2020-240570
摘要
Primary hyperparathyroidism is characterised by autonomous production of parathyroid hormone resulting in hypercalcaemia. It is estimated that 12% of these patients present with peptic ulcer-related symptoms. The pathophysiological mechanism is not well established, but studies reveal serum calcium activating gastrin cell calcium receptors ultimately resulting in increased gastric acid production leading to peptic ulcer disease. A patient presented acutely to our service with peptic ulcer perforation in the context of incidentally elevated serum calcium levels. Further inpatient investigations lead to the diagnosis of primary hyperparathyroidism as the first manifestation of this patient's disease.
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