番茄红素
DNA损伤
大肠杆菌
活性氧
氧化应激
DNA修复
DNA
化学
SOS响应
生物化学
羟基自由基
激进的
类胡萝卜素
基因
作者
Won Young Lee,Dong Gun Lee
出处
期刊:Journal of Microbiology and Biotechnology
[Journal of Microbiology and Biotechnology]
日期:2014-09-28
卷期号:24 (9): 1232-1237
被引量:23
标识
DOI:10.4014/jmb.1406.06009
摘要
Lycopene, which is a well-known red carotenoid pigment, has been drawing scientific interest because of its potential biological functions. The current study reports that lycopene acts as a bactericidal agent by inducing reactive oxygen species (ROS)-mediated DNA damage in Escherichia coli. Lycopene treatment elevated the level of ROS-in particular, hydroxyl radicals ((•)OH) -which can damage DNA in E. coli. Lycopene-induced DNA damage in bacteria was confirmed and we also observed cell filamentation caused by cell division arrest, an indirect marker of the DNA damage repair system, in lycopene-treated E. coli. Increased RecA expression was observed, indicating activation of the DNA repair system (SOS response). To summarize, lycopene exerts its antibacterial effects by inducing (•)OH -mediated DNA damage that cannot be ameliorated by the SOS response. Lycopene may be a clinically useful adjuvant for current antimicrobial therapies.
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