In order to reduce hydrogen sulfide of running,leak aging and others in the gas of mining,gathering and processing,a new type of zinc oxide desulfurizer was developed, based on the method of chemical absorption desulfurization. The desulfurization was compounded from zinc oxide and organic acid. The desulfurization for removing the hydrogen sulfide in natural gas had strong absorption effect,through the evaluation of dosage,duration and the desulfurization efficiency.