Dynamic changes of IL-2,sIL-2R,IL-6and IL-8 in children with mycoplasma pneumonia and their clinical significance

Objective To observe the dynamic changes of IL-2,sIL-2R,IL-6 and IL-8 in children with mycoplasma pneumonia(MPP) and to study their clinical significance.Methods The serum levels of IL-2,sIL-2R,IL-6 and IL-8 in 40 children with MPP during the acute stage and convalescent stage were examined with double-antibody sandwich enzyme-linked immunosobent assay,and the results were compared with those in 30 normal children.Results The levels of sIL-2R,IL-6 and IL-8 were higher and IL-2 was lower during acute stage than those in the normal subjects(P0.01).Compared those during the convalescent stage,the level of IL-2was higher and sIL-2R,IL-6 and IL-8 were lower(P0.01) during the acute stage.There were not any significant differences of the levels of these four substances between the normal children and MPP children during the convalescent stage.Conclusion The cellular immune function of children with MPP is impaired and the changes of IL-2,sIL-2R,IL-6 and IL-8 can be used to evaluate the curative effects and prognosis of MPP in children.