Ubiquitin-like Protein FAT10-mediated Proteasome Degradation

Ubiquitin-proteasome system(UPS) is an important pathway to degrade intracellular proteins,while linkage of a protein with a single ubiquitin does not serve as a degradation signal for the proteasome.Poly-ubiquitin chains via the enzyme cascades with the target proteins lead to efficient proteasomal degradation.Ubiquitin-like modifiers have not been shown to directly meditate proteasomal degradation except for human leukocyte antigen F-associated transcript10(FAT10) which has a similar structure and function with ubiquitin,moreover,in contrast to ubiquitin,a single FAT10 suffices to bind to the 26 S proteasome and to efficiently mediate proteasomal degradation in a ubiquitin-independent manner.Thus,FAT10-proteasome system(FPS) is an independent protein degradation pathway.In recent years,some studies have found that the FPS plays a significant role in the regulation of cytobiology functions,and the FPS has also attracted more widespread attention.Here,we review the date on FAT10-proteasome degradation pathway.