癌症干细胞
癌症研究
脂质过氧化
癌细胞
诱导剂
癌症
程序性细胞死亡
GPX4
生物
细胞生物学
干细胞
细胞凋亡
抗氧化剂
基因
生物化学
遗传学
过氧化氢酶
谷胱甘肽过氧化物酶
作者
Tianqi Xu,Yixiong Liu,Zhao Zhang,Jin Liu,Jia Chai,Yanru Yang,Sai-Jie Zuo,Mingyang Li,Qingge Jia
标识
DOI:10.1016/j.prp.2023.154492
摘要
Ferroptosis is an iron-dependent form of RCD correlates with the accumulation of markers of lipid peroxidation. Bulks of studies focusing on revealing ferroptosis and its regulators involved in oncogenic pathways. Connection between iron metabolism and abnormal iron metabolism in CSCs synergistically making ferroptosis a target process of great potential in combating with CSCs to improve therapeutic effectiveness and reverse resistance. Ferroptosis inducers could specifically induce CSCs death in tumors, predisposing ferroptosis to a target in killing CSCs to overcome cancer resistances. By ferroptosis induction and other cell death pathways in CSCs, cancer therapeutic outcome would be improved.
科研通智能强力驱动
Strongly Powered by AbleSci AI