纳米材料
放射治疗
化学
纳米技术
纳米颗粒
高能
癌症研究
材料科学
医学
工程物理
物理
内科学
作者
Xiu Zhao,Jun Li,Qiongwei Wang,Zhenzhong Zhang,Junjie Liu,Jinjin Shi
标识
DOI:10.1002/cjoc.202300132
摘要
Comprehensive Summary Radiotherapy is a mainstay treatment for malignant tumors in clinical practice. However, enhancing radiation damage to tumor cells meanwhile sparing normal tissues is still a great challenge in radiotherapy. Nanomaterials with high atomic number ( Z ) values are promising radiosensitizers by promoting the radiation energy deposition in irradiated tumor cells, thus enhancing the therapeutic ratio of radiotherapy. In this review, we described the mechanisms of high‐ Z element based‐radiosensitizers and systematically summarized the recent progress on high‐ Z metal‐based nanomaterials, including high‐ Z metal‐based nanoparticles, high‐ Z metal‐based nanoscale metal‐organic frameworks and high‐ Z metal‐doping nanomaterials. Finally, further potential and challenges in this field were discussed.
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