电极
心脏毒性
计算机科学
氧化铟锡
信号(编程语言)
炸薯条
过程(计算)
纳米技术
材料科学
生物医学工程
工程类
医学
化学
薄膜
电信
物理化学
程序设计语言
外科
化疗
操作系统
作者
Zhangjie Li,Fan Liu,Chenyang Zhou,Feifan Wang,Kangyi Lu,Yijun Liu,Lian Xuan,Xiaolin Wang
出处
期刊:Lab on a Chip
[The Royal Society of Chemistry]
日期:2024-01-01
卷期号:24 (7): 1903-1917
摘要
Drug-induced cardiotoxicity is a significant contributor to drug recalls, primarily attributed to limitations in existing drug screening platforms. Traditional heart-on-a-chip platforms often employ metallic electrodes to record cardiomyocyte electrical signals. However, this approach hinders direct cardiomyocyte morphology observation and typically yields limited functionality. Consequently, this limitation may lead to an incomplete understanding of cardiomyocyte characteristics. To address these challenges, we introduce a multifunctional cardiac microphysiological system featuring transparent indium tin oxide electrodes. This innovative design aims to overcome the limitations of conventional heart-on-a-chip systems where metal electrodes interfere with the observation of cells and increase the difficulty of subsequent image processing of cell images. In addition to facilitating optical measurement combined with image processing capabilities, this system integrates a range of electrodes with diverse functionalities. These electrodes can realize cellular electrical stimulation, field potential monitoring, and impedance change tracking, enabling a comprehensive investigation of various cardiomyocyte traits. To demonstrate its versatility, we investigate the effects of four cardiac drugs with distinct pharmacological profiles on cardiomyocytes using this system. This platform provides a means for quantitatively and predictively assessing cardiac toxicity, which could be applied to conduct a comprehensive evaluation during the drug discovery process.
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