自噬
泛素连接酶
修剪
细胞生物学
泛素
炎症
血管平滑肌
医学
病理生理学
细胞内
信号蛋白
信号转导
细胞凋亡
免疫学
生物
病理
生物化学
平滑肌
内科学
操作系统
基因
计算机科学
作者
Xinxin Chen,Xiaolong Chen
出处
期刊:Current Vascular Pharmacology
[Bentham Science]
日期:2024-01-01
卷期号:22 (1): 11-18
标识
DOI:10.2174/0115701611241848231114111618
摘要
There are more than 80 different tripartite motifs (TRIM) proteins within the E3 ubiquitin ligase subfamily, including proteins that regulate intracellular signaling, apoptosis, autophagy, proliferation, inflammation, and immunity through the ubiquitination of target proteins. Studies conducted in recent years have unraveled the importance of TRIM proteins in the pathophysiology of vascular diseases. In this review, we describe the effects of TRIM proteins on vascular endothelial cells, smooth muscle cells, heart, and lungs. In particular, we discuss the potential mechanisms by which TRIMs regulate diseases and shed light on the potential therapeutic applications of TRIMs.
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