透皮
可穿戴计算机
材料科学
压电
药物输送
透皮贴片
生物医学工程
计算机科学
纳米技术
嵌入式系统
医学
药理学
复合材料
作者
Wei E. I. Sha,Yi Li,Jie Liang,Lei Zhang,Jianhua Zhang
摘要
Transdermal drug delivery refers to a drug delivery route that delivers drugs through the skin to produce local or systemic therapeutic effects. In this work, we propose a parallel valveless piezoelectric micropump integrated with hollow microneedle array, which can be used in flexible wearable transdermal drug delivery systems. The device consists of two valveless piezoelectric micropump, a hollow microneedle array and an electrical control module. The main structure of micropump and the hollow microneedle array are fabricated using 3D printing technology. The valveless piezoelectric micropump adopts a parallel dualpump structure with asynchronous drive, which achieves a full forward flow at the outlet and reduces the influence of backflow on the stability of the system. In addition, the parallel dual‐pump structure proposed in this work can be extended to a multimicropump parallel structure. We hope to fabricate small‐size micropump arrays on flexible substrates and integrate them into flexible wearable transdermal drug delivery systems.
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