地氯酸
细胞壁
脂质Ⅱ
金融时报
细菌外膜
抗生素
微生物学
细菌
生物
细菌细胞结构
金黄色葡萄球菌
细胞分裂
青霉素结合蛋白
抗菌剂
青霉素
细胞膜
膜蛋白
生物化学
细胞
肽聚糖
膜
大肠杆菌
基因
遗传学
作者
George A Naclerio,Herman O. Sintim
出处
期刊:Future Medicinal Chemistry
[Newlands Press Ltd]
日期:2020-07-01
卷期号:12 (13): 1253-1279
被引量:21
标识
DOI:10.4155/fmc-2020-0046
摘要
The rise of antibiotic-resistant infections has been well documented and the need for novel antibiotics cannot be overemphasized. US FDA approved antibiotics target only a small fraction of bacterial cell wall or membrane components, well-validated antimicrobial targets. In this review, we highlight small molecules that inhibit relatively unexplored cell wall and membrane targets. Some of these targets include teichoic acids-related proteins (DltA, LtaS, TarG and TarO), lipid II, Mur family enzymes, components of LPS assembly (MsbA, LptA, LptB and LptD), penicillin-binding protein 2a in methicillin-resistant Staphylococcus aureus, outer membrane protein transport (such as LepB and BamA) and lipoprotein transport components (LspA, LolC, LolD and LolE). Inhibitors of SecA, cell division protein, FtsZ and compounds that kill persister cells via membrane targeting are also covered.
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