A superior G-quadruplex DNAzyme through functionalized modification of the hemin cofactor

Unlike previous studies that are generally based on the native cofactor, chemical modifications of the hemin structure through introducing new functionalities are proposed to enhance the catalytic efficiency of the hemin/G-quadruplex (hG4) DNAzyme. Functionalized hemin cofactors will highly improve the performance of the hG4 DNAzyme in future applications.