光动力疗法
单线态氧
紧身衣
赫拉
光敏剂
阿霉素
连接器
生物相容性
支柱
药物输送
药品
化学
材料科学
金属有机骨架
组合化学
化疗
癌症研究
纳米技术
光化学
药理学
氧气
有机化学
医学
生物化学
体外
荧光
外科
计算机科学
吸附
量子力学
结构工程
操作系统
物理
工程类
作者
Meng Yang,Yingying Du,Yanxin Lin,Yu Su,Ruonan Li,Yaqing Feng,Shuxian Meng
标识
DOI:10.1016/j.dyepig.2021.109174
摘要
The combination of chemotherapy and photodynamic therapy has been proved to be a promising therapy for drug-resistant cancers. In this study, we report, for the first time, a novel two-fold interpenetration pillar-layered metal-organic frameworks (MOFs) material, using BODIPY-derivate bipyridine as linker and Photosensitizer (PS), named BBP-MOFs, was successfully synthesized to serve as a drug carrier and Photodynamic agent simultaneously. The BBP-MOFs could generate singlet oxygen (1O2) to perform PDT under 660 nm light irradiation, in the meantime, the anticancer drugs doxorubicin (DOX) could be loaded for chemotherapy. The results showed that BBP-MOFs exhibited a high drug loading content of 49.7% a controlled drug release and ideal biocompatibility. This DOX loaded BBP-MOFs was readily taken up by HeLa cells, and high levels of 1O2 were generated under light irradiation. This work provided strong evidence for BBP-MOFs as a promising new anticancer drug carrier and PDT candidate, the PDT and chemotherapy combined synergistic therapy revealed high therapeutic efficacy for cancer cells.
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