医学
骨矿物
脆性骨折
脆弱性
内科学
骨质疏松症
物理化学
化学
作者
Jeff Ehresman,Andrew Schilling,Xianghong Yang,Zach Pennington,Ali Ahmed,Ethan Cottrill,Daniel Lubelski,Majid Khan,Kendall F. Moseley,Daniel M. Sciubba
标识
DOI:10.1016/j.spinee.2020.05.540
摘要
Abstract Background Current evidence suggests that dual-energy x-ray absorptiometry (DXA) scans, the conventional method defining osteoporosis, is underutilized and, when used, may underestimate patient risk for skeletal fragility. It has recently been suggested that other imaging modalities may better estimate bone quality, such as the magnetic resonance imaging (MRI)-based vertebral bone quality (VBQ) score which also may assess vertebral compression fracture risk in patients with spine metastases. Purpose To evaluate whether VBQ score is predictive of fragility fractures in a population with pre-existing low bone density and at high-risk for fracture. Study Design/Setting Retrospective single-center cohort. Patient Sample Patients followed at a metabolic bone clinic for osteopenia and/or osteoporosis. Outcome Measures Radiographically-documented new-onset fragility fracture. Methods Patients with a DXA and MRI scans at the time of consultation and ≥2-year follow-up were included. Details were gathered about patient demographics, health history, current medication use, and serological studies of kidney function and bone turnover. For each patient, VBQ score was calculated using T1-weighted lumbar MRI images. Univariable and multivariable analyses were used to identify the independent predictors of a new fragility fracture. To support the construct validity of VBQ, patient VBQ scores were compared to those in a cohort of 45 healthy adults. Results Seventy-two (39.1%) study participants suffered fragility fractures, the occurrence of which was associated with higher VBQ score (3.50 vs. 3.01; p Conclusions Here we demonstrate the novel, MRI-derived VBQ score is both an independent predictor of fragility fracture in at-risk patients and a superior predictor of fracture risk than DXA-measured BMD. Given the frequency with which MRIs are obtained by patients undergoing spine surgery consultation, we believe the VBQ score could be a valuable tool for estimating bone quality in order to optimize the management of these patients.
科研通智能强力驱动
Strongly Powered by AbleSci AI