光热治疗
材料科学
共轭体系
二硫化钼
纳米材料
结合
内吞作用
纳米探针
荧光
癌细胞
光子上转换
纳米技术
生物物理学
纳米颗粒
发光
癌症
化学
光电子学
聚合物
细胞
光学
生物化学
医学
数学
物理
冶金
生物
复合材料
数学分析
内科学
作者
Myeonghwan Shin,Eun-Yeong Park,Seulgi Han,Ho Sang Jung,Do Hee Keum,Geon‐Hui Lee,Taeyeon Kim,Chulhong Kim,Ki Su Kim,Seok Hyun Yun,Sei Kwang Hahn
标识
DOI:10.1002/adhm.201801036
摘要
Among various 2D nanomaterials, molybdenum disulfide (MoS2 ) exhibits unique visible photoluminescence with high absorption at the near-infrared (NIR) range. Despite these optical properties, the efforts to use MoS2 nanomaterials for optical imaging and photothermal therapy are hampered by their instability and low intracellular delivery efficiency. Multifunctional MoS2 conjugated with hyaluronate (HA) for cancer theranosis is reported herein. HA facilitates the delivery of MoS2 to tumor cells by the HA-receptor mediated endocytosis. In BALB/c nude mice inoculated with a colorectal cancer cell line of HCT116, HA-MoS2 conjugates appear to be accumulated in the primary tumor at a content more than that in the liver and kidney. The disulfide bonding between MoS2 and thiolated HA seems to degrade in the cytoplasm, releasing MoS2 sheets in stacks and enhancing luminescence efficiency. The HA-MoS2 conjugates are readily detected via photoacoustic imaging as well as upconversion and downconversion fluorescence imaging. With NIR light illumination, HA-MoS2 conjugates enable highly effective photothermal tumor ablation. All these results confirm the promising potential of HA-MoS2 conjugates for cancer theranosis.
科研通智能强力驱动
Strongly Powered by AbleSci AI