结肠炎
细菌
致病菌
微生物学
炎症
细胞内
沙门氏菌
右旋糖酐
化学
生物
免疫学
生物化学
遗传学
作者
Kang Ding,Yanyan Tan,Yang Ding,Yuan Fang,Yun Xu,Jian Fang,Da-Chao Xu,Hui Zhang,Wei Lü,Meng Li,Shi-Cai Huang,Mengling Cai,Yan Song,Ye Ding,Sumin Zhang
摘要
In this article, we aim to examine the novel effects of β-sitosterol on murine experimental colitis. β-Sitosterol significantly reduces the weight loss, colon length, and alleviated microscopic appearances of colitis induced by dextran sulfate sodium. This compound also decreases the levels of TNF-α, IL-6, and IL-1β in intestinal tissue of mice with experimental colitis in a concentration-dependent manner. β-Sitosterol treatment to intestinal epithelial cells significantly increases expression of antimicrobial peptides and reduces survival of intracellular Salmonella typhimurium. These results showed the multiple effects of β-sitosterol against pathogenic bacteria for a novel approach to the treatment of colonic inflammation.
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