大麻酚
化学
环加成
产量(工程)
立体化学
高压
双环分子
药物化学
有机化学
催化作用
大麻
工程类
冶金
材料科学
精神科
工程物理
心理学
作者
Eleonora Ballerini,Lucio Minuti,Oriana Piermatti,Ferdinando Pizzo
摘要
Diels−Alder cycloaddition reactions of 3-cyanocoumarin, hydroxy-substituted 3-cyanocoumarins and mesyl-substituted 3-cyano-coumarins with methyl-1,3-butadienes carried out under high pressure (11 kbar) are reported. Activation by high pressure allows these reactions to proceed satisfactorily under mild conditions to produce 6a-cyano-hydroxy- and 6a-cyano-mesyl-tetrahydro-6H-benzo[c]chromen-6-ones in moderate to excellent yield. The synthesis of cis-1-hydroxy-9-methyl-3-pentyl-6a,7,10,10a-tetrahydro-benzo[c]chromen-6-one as precursor of Δ6-3,4-cis-cannabidiol (Δ6-cis-CBD) and Δ8-cis-tetrahydrocannabinol (Δ8-cis-THC) is outlined.
科研通智能强力驱动
Strongly Powered by AbleSci AI