医学
微泡
小RNA
疾病
转移
肥胖
表型
癌症
癌症研究
糖尿病
2型糖尿病
生物标志物
生物信息学
内科学
免疫学
内分泌学
基因
生物
遗传学
作者
Naser Jafari,Pablo Llevenes,Gerald V. Denis
标识
DOI:10.1038/s41574-022-00666-7
摘要
Exosomes include plasma-transported vesicles that are secreted by human tissues and reflect metabolic status. The profile of exosomes (particularly microRNA content) is altered in metabolic disease. In type 2 diabetes mellitus, exosomes circulating in plasma induce transcriptional changes related to tumour progression and pro-metastatic phenotypes in target cancer cells, potentially linking obesity to cancer progression and metastasis.
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