A series of bottom‐emitting Blue OLEDs with an optimal efficiency and lifetime are successfully fabricated by introducing different electrical material combinations. Distinct EQE‐Current density performance are analyzed and validated by the transient EL response, which reveal the Triplet‐Triplet Annihilation (TTA) impact differently. Overall, an efficiency‐lifetime‐trade‐off have been obtained, with 60% Lifetime promotion, 3% EQE decline and 6% voltage rise. The investigation of mechanism and experimental validation provide a method in long‐lifetime and high‐efficiency device design.