微管
秋水仙碱
药效团
微管蛋白
细胞骨架
中期
微管聚合
有丝分裂
化学
结合位点
机制(生物学)
细胞生物学
生物物理学
生物
细胞
生物化学
遗传学
物理
染色体
量子力学
基因
作者
Jing Chen,Tao Liu,Xiaowu Dong,Yongzhou Hu
标识
DOI:10.2174/138955709789055234
摘要
Microtubules are cytoskeletal components that play important roles in a number of cellular processes. Colchicine binding site inhibitors (CSIs) is one major class of tubulin polymerization inhibitors, inhibiting microtubule polymerization and blocking cell proliferation at metaphase during mitosis. Many CSIs were discovered or designed and synthesized as anticancer agents in the past several years and great progress had been made. Here, we discuss the insights gained so far relevant to the mechanism of CSIs and their common pharmacophore. The recent development of CSIs with their biological activity and structure-activity relationship (SAR) are also reviewed. Keywords: Microtubules, colchicine binding site, inhibitor, SAR, anticancer
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