神经科学
心理学
功能磁共振成像
基于体素的形态计量学
神经影像学
功能连接
医学
静息状态功能磁共振成像
强迫症
体素
作者
Seung-Goo Kim,Wi Hoon Jung,Sung Nyun Kim,Joon Hwan Jang,Jun Soo Kwon
标识
DOI:10.3389/fnhum.2013.00302
摘要
As one of the most widely accepted neuroanatomical models on obsessive-compulsive disorder (OCD), it has been hypothesized that imbalance between an excitatory direct (ventral) pathway and an inhibitory indirect (dorsal) pathway in cortico-striato-thalamic circuit underlies the emergence of OCD. Here we examine the structural network in drug-free patients with OCD in terms of graph theoretical measures for the first time. We used a measure called efficiency which quantifies how a node transfers information efficiently. To construct brain networks, cortical thickness was automatically estimated using T1-weighted magnetic resonance imaging. We found that the network of the OCD patients was as efficient as that of healthy controls so that the both networks were in the small-world regime. More importantly, however, disparity between the dorsal and the ventral networks in the OCD patients was found in terms of graph theoretical measures, suggesting a positive evidence to the imbalance theory on the underlying pathophysiology of OCD.
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